Sequencing the Human Genome: 25 Years On

A one-day colloquium from the Académie des sciences and the Académie nationale de médecine, in the Bettencourt auditorium at the Institut de France, marking 25 years since the human genome was first sequenced and asking what that pioneering work actually produced. The morning covers the unresolved gaps left by the first sequence, the mutation-and-selection dynamics behind sequence diversity, what spatial transcriptomics is revealing about the brain, and how the genome's three-dimensional structure and epigenetic landscape govern expression. The afternoon turns to medical applications in cancer, vascular disease and deafness. Bilingual French and English, 09:00 to 19:00, free, and aimed at a scientific or well-informed general audience. Why go: the clearest read available this year on where genomics actually got to, from the people who did the work rather than from a vendor deck. Best for anyone building in biotech, genomics or health data.